Officers were called to Ningwood Hill in Shalfleet at 1.40am on Saturday, 23 June, after receiving reports of a single-vehicle collision involving a silver Renault LL29 Van.
The driver, 45, from the Isle of Wight, died at the scene.
His next of kin have been notified, and they are being assisted by specialist officers.
We are requesting that anyone who witnessed the collision or saw the vehicle in the area prior to the collision contact us.
Were you in the neighbourhood at the time? Did you see the vehicle before the collision, or do you have dash-cam video?
Anyone with information can contact 44220295763 or Operation Happen by going online or calling 101.
Alternatively, you can contact Crimestoppers online or by calling 0800 555 111 anonymously.